DEBASIS DAS LAB

Peer reviewed journal publications:

• B.R. Bhaskar, L. Yadav, M. Sriram, K. Sanghrajka, M. Gupta, Boby K. V., R. K. Nellikka, & D. Das. Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site. Nature Communications, 2024 May 16;15(1):4132. doi: 10.1038/s41467-024-46965-7.

 

• S. Patil, K. Sanghrajka, M. Sriram, A. Chakraborty, S. Majumdar, B.R. Bhaskar, & D. Das. Synaptobrevin2 monomers and dimers differentially engage to regulate the functional trans-SNARE assembly. Life Sci Alliance, 2024 Jan 18;7(4):e202402568. doi: 10.26508/lsa.202402568.

 

• K. C. Courtney, T. Mandal, Y. Li, N. Mehta, D. Das, Q. Cui, & E.R.Chapman. Synaptotagmin 7 outperforms synaptotagmin 1 to promote the formation of large, stable fusion pores via robust membrane penetration. Nature Communications, 2024 Jan 4;15(1):262. doi: 10.1038/s41467-023-44414-5.

 

• R. K. Nellikka, B. R. Bhaskar, K. Sanghrajka, S. S. Patil, and D. Das. α-Synuclein kinetically regulates the nascent fusion pore dynamics. Proc. Natl. Acad. Sci USA 118 (34) e2021742118; https://doi.org/10.1073/pnas.2021742118 (August 24, 2021).

 

• D.Das, H. Bao, K. C. Courtney, L. Wu & E.R. Chapman. Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores. Nature Communications, 2020 11, 231.

 

• H. Bao*,D.Das*, NA Courtney, Y Jiang, J Brigugli, X Lou, D Roston, Q Cui, B Chanda and ER Chapman. Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties. Nature 554, 260–263 (2018). [* equal contribution] [Highlighted Article. US Weekly, Science Daily, Physics.org etc.] (Selected as F1000Prime article: DOI: 10.3410/f.732585766.793543805).

 

• D.Das & BA Krantz. Peptide and Proton Driven Allosteric Clamps Catalyze Anthrax Toxin Translocation across Membranes. Proc. Natl. Acad. Sci. USA 13(34): 9611-6 (2016).

 

• D.Das & BA Krantz. Secondary structure preferences of the allosteric clamps in the anthrax toxin protective antigen translocase. J Mol. Biol., 429(5): 753-762 (2017).

 

• D.Das, D. Samanta, A. Bhattacharya, A. Basu, A. Das, J. Ghosh, A. Chakrabarti & C. Das Gupta. A possible role of the full-length nascent protein in post-translational ribosome recycling. PLoS One 12(1): e0170333 (2017). doi: 10.1371/journal.pone.0170333.

 

• E. Biondi, J.D. Lane, D.Das, S. Dasgupta, J.A. Piccirilli, S. Hoshika, K.M. Bradley, B.A. Krantz & S.A. Benner. Aptamers Targeting Anthrax Protective Antigen using Laboratory In Vitro Selection with an Expanded Genetic Alphabet. Nucleic Acids Res 44 (20): 9565-9577 (2016).

 

• K. Ghosal, J.M. Colby, D.Das, S.T. Joy, P.S. Arora, B.A. Krantz. Dynamic Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation through the Anthrax Toxin Protective Antigen Channel. J Mol. Biol. 429(6): 900-910 (2017).

 

• D.Das, D. Samanta, S. Hasan, A. Das, A. Bhattacharya, S. Dasgupta, A. Chakrabarti, P. Ghorai, & C. Das Gupta. Identical RNA-protein interactions in vivo & in vitro and a scheme of folding the newly synthesized proteins by ribosomes. J. Biol. Chemistry (2012).

 

• A. Das, J. Ghosh, A. Bhattacharya, D. Samanta, D.Das, C. Das Gupta. Involvement of mitochondrial ribosomal proteins in ribosomal RNA mediated protein folding. J. Biol. Chemistry 286(51): 43771-81 (2011).

 

• D.Das, D. Samanta, A. Das, J. Ghosh, A. Bhattacharya, A. Basu, A. Chakrabarti, C. Das Gupta. Ribosome: The Structure-Function Relation and a New Paradigm to the Protein Folding Problem. Israel J. of Chemistry (Special Issue to celebrate the Nobel Prize on Ribosome: Ribosome Chemistry) (2010).

 

• D.Das, A. Das, D. Samanta, J. Ghosh, S. Dasgupta, A. Bhattacharya, A. Basu, S. Sanyal, C. DasGupta. Role of Ribosome in Protein Folding. Biotechnology J. 3(8): 999-1009 (2008).

 

• A. Basu, D. Samanta, D.Das, S. Chowdhury, A. Bhattacharya, J. Ghosh, A. Das, C. Dasgupta. In vitro protein folding by E. coli ribosome: unfolded protein splitting 70S to interact with 50S subunit. Biochem. Biophys. Res. Commun. 366(2): 598-603 (2008).

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• D. Samanta, D. Mukhopadhyay, S. Chowdhury, J. Ghosh, S. Pal, A. Basu, A. Bhattacharya , A. Das, D.Das, C. DasGupta. Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions. J. Bacteriology 190(9): 3344-52 (2008).

 

• A. Basu, D. Samanta, A. Bhattacharya, A. Das, D.Das, C. DasGupta. Protein folding following synthesis in vitro and in vivo: association of newly synthesized protein with 50S subunit of E. coli ribosome. Biochem. Biophys. Res. Commun. 366(2): 592-7 (2008).

 

  Book chapter:​

• D. Samanta, A. Das, D.Das, A. Bhattacharya, A. Basu, J. Ghosh, C. DasGupta, Ribosome Assisted Protein Folding: Some of its Biological Implications; Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions; 2010; ISBN: 978-1-61761-259-6, NOVA Publishers.